Progressively Increased M50 Responses to Repeated Sounds in Autism Spectrum Disorder with Auditory Hypersensitivity: A Magnetoencephalographic Study
نویسندگان
چکیده
The aim of this study was to investigate the differential time-course responses of the auditory cortex to repeated auditory stimuli in children with autism spectrum disorder (ASD) showing auditory hypersensitivity. Auditory-evoked field values were obtained from 21 boys with ASD (12 with and 9 without auditory hypersensitivity) and 15 age-matched typically developing controls. M50 dipole moments were significantly increased during the time-course study only in the ASD with auditory hypersensitivity compared with those for the other two groups. The boys having ASD with auditory hypersensitivity also showed more prolonged response duration than those in the other two groups. The response duration was significantly related to the severity of auditory hypersensitivity. We propose that auditory hypersensitivity is associated with decreased inhibitory processing, possibly resulting from an abnormal sensory gating system or dysfunction of inhibitory interneurons.
منابع مشابه
Auditory processing skills in brainstem level of autistic children: A Review Study
Aims: Autism is a pervasive developmental disorder. Deficit in sensory functions is one of the characteristics of people with autism, and usually these people show abnormality in processing and correct interpretation of auditory information. Also people with Autism show problems in communicating with others. This review article deals with the accurate understanding of Auditory processing skills...
متن کاملaudiTory hyPersensiTiviTy and auTism sPeCTrum disorders : an emoTional resPonse
REPRINTED WITH PERMISSION • AUTISM SCIENCE DIGEST: THE JOURNAL OF AUTISMONE • ISSUE 04 audiTory hypersensiTiviTy and auTism specTrum disorders One concern parents and professionals may have with children who have been diagnosed with an autism spectrum disorder (ASD) is that some of these children cannot tolerate listening to certain sounds. Often, parents observe that the children put their han...
متن کاملAn Emotional Response
REPRINTED WITH PERMISSION • AUTISM SCIENCE DIGEST: THE JOURNAL OF AUTISMONE • ISSUE 04 audiTory hypersensiTiviTy and auTism specTrum disorders One concern parents and professionals may have with children who have been diagnosed with an autism spectrum disorder (ASD) is that some of these children cannot tolerate listening to certain sounds. Often, parents observe that the children put their han...
متن کاملCortical activation during attention to sound in autism spectrum disorders.
Individuals with autism spectrum disorders (ASDs) can demonstrate hypersensitivity to sounds as well as a lack of awareness of them. Several functional imaging studies have suggested an abnormal response in the auditory cortex of such subjects, but it is not known whether these subjects have dysfunction in the auditory cortex or are simply not listening. We measured changes in blood oxygenated ...
متن کاملCase study: auditory brain responses in a minimally verbal child with autism and cerebral palsy
An estimated 30% of individuals with autism spectrum disorders (ASD) remain minimally verbal into late childhood, but research on cognition and brain function in ASD focuses almost exclusively on those with good or only moderately impaired language. Here we present a case study investigating auditory processing of GM, a nonverbal child with ASD and cerebral palsy. At the age of 8 years, GM was ...
متن کامل